This report highlights the remarkable progress made by the Centre in the past year towards its vision of driving 3Rs advancement for improved animal welfare and better science in Switzerland. It is with great honour that I take over the presidency and recognise the significant efforts made by my predecessor, Katharina Riklin, in supporting the 3RCC through the Centre’s formative period. I would also like to acknowledge the confidence 3RCC’s members have placed in me to champion the interests of the 3Rs. With my long-standing experience in communication and insight into life sciences, I’m excited to support the organisation in its future development.