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Moving towards Personalized Medicine: Precision Cut Skin Slices to Model Gene-Responsive Signatures for Novel and Existing Therapies for Systemic Sclerosis Patients

by caitlin.sadowski@icloud.com | Jul 10, 2025 | Funded Projects

BACKGROUND The Centre of Experimental Rheumatology specializes in the investigation of rheumatic and skeletal disorders, including systemic sclerosis (SSc). SSc is a paradigm fibrotic disease characterized by multi-organ fibrosis, including the skin. Currently, tools...

Algorithmic Breeding Planning

by caitlin.sadowski@icloud.com | Jul 10, 2025 | Funded Projects

An automated system for the assessment of pain and wellbeing in laboratory mice

An automated system for the assessment of pain and wellbeing in laboratory mice

by caitlin.sadowski@icloud.com | Jul 10, 2025 | Funded Projects

APPLICATION ABSTRACT Monitoring the well-being of mice in research labs is often overlooked, and current methods rely on subjective observations, leading to potential biases and variations between different observers. Recent advancements in machine vision and learning...
Evaluation of environmental enrichments for mice

Evaluation of environmental enrichments for mice

by caitlin.sadowski@icloud.com | Jul 10, 2025 | Funded Projects

BACKGROUND High-quality environmental enrichment ameliorates the quality of life of laboratory mice. Commercially validated enrichment should still be evaluated in house. Three environmental enrichments are evaluated though behavioural observation in laboratory mice....
Providing immunocompetence to human microtissue bladder models

Providing immunocompetence to human microtissue bladder models

by caitlin.sadowski@icloud.com | Jul 10, 2025 | Funded Projects

BACKGROUND At my home lab, we established several human bladder microtissue models to understand host-uropathogen interactions in patient-like scenarios, to be tested for novel urinary tract infections (UTI) therapeutics. However, they still lack the immune cell...
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